Along with Eccles, Moor were promoted at the end of last season, and currently lie in tenth place in the table.
The two teams have not met for the last five years, and it was back in September 2018 when Widnes travelled to Green Lane.
On that occasion, the 'red-and-blacks' came from behind to get their noses in front, only to see the home convert a late penalty to win a high scoring contest.
The game kicks off at 2.00pm.
In the other senior matches; the Seconds and Thirds are both at home to Southport and Wirral respectively. These games kick off at 2.15pm.